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Symex CML500

The Symex CML 500 is a high-performance vacuum homogenizer mixer designed for the production of demanding products in the pharmaceutical and cosmetics industries.

This system combines mixing, dispersing, homogenizing, heating, cooling, and vacuum processing in a single closed unit, enabling precise and reproducible production from pilot scale up to industrial applications. Such systems are specifically engineered for complex processes with stringent quality requirements.

Technical Highlights of the Symex CML 500

Vessel
- Usable volume: approx. 500 liters
- Total volume: approx. 780 liters
- Minimum volume: approx. 125–160 liters
- Product space pressure range: -1 / +2 bar
- Product temperature: up to approx. 133 °C
- Heating jacket: up to +4 bar / 151 °C
- Manufactured according to AD 2000 standards
- The vessel is fully pressure and vacuum resistant, ensuring safe operation under demanding conditions.
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Agitator
- Anchor agitator with flow breakers
- Speed range: approx. 11–66 rpm
- Power: approx. 7.5 kW
- Frequency-controlled
- Designed for high-viscosity products
- The agitator provides uniform mixing and optimal heat transfer.

Homogenizer
- Power: approx. 16–20 kW
- Speed: up to approx. 3,000 rpm
- High shear performance for fine dispersion
- Rotor/stator system
- The homogenizer ensures stable emulsions and reproducible product quality.

Vacuum System
- Operation under vacuum possible
- Liquid ring vacuum pump (external)
- Pressure and vacuum monitoring
- Vacuum operation significantly reduces air entrainment and improves product quality.

Heating & Cooling
- Double-walled vessel (2-zone heating)
- Precise temperature control
- Even heat distribution
- CIP system

Multiple CIP Connections
- Rotating cleaning nozzles (360°)
- Cleaning of the entire product area including pipelines

Material Feeding
- Direct suction of liquids and powders
- Suction into the homogenizer area
- Fast and low-loss processing
- Such integrated feeding and circulation systems enable highly efficient process control.

Additional Equipment
- Hydraulic lid lifting system
- Multi-port bell with several connection options
- Sight glass with double wiper
- Vessel lighting
- Dosing vessel (approx. 8 liters)
- Sampling valve
- Diaphragm and disk valves
- Circulation lines for homogenization and CIP
- Control & Operation

The system features a modern operating concept:
- Touch panel control
- Setting of speeds and run times
- Process monitoring (pressure, temperature, speed)
- Automatic and manual operation modes
- Fault messages and safety features

Advantages of the Symex CML 500

- Combination of all process steps in one system
- High process safety due to closed design
- Reproducible and stable product quality
- Suitable for high-viscosity and sensitive products
- Hygienic design (GMP compliant)
- Flexible application for various batch sizes

Delivery & Processing
- Delivery Ex-Works
- Turn-key project possible (incl. commissioning)
- International shipping available

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